Professor Marcel Ottens
Delft University of Technology
Model-based High Throughput Process Development
With the increase in computational power over the last decades, the use of modeling and simulation in process design for the (petro)chemical industry has become common ground. Computational tools like ASPEN are standard in the design and operational analysis of (petro)chemical plants. However, in the bio pharmaceutical field, such modeling and simulation techniques are only recently being investigated for use and (potential) implementation. Being the workhorse of purification in the biopharmaceutical industry, chromatography is a good candidate for this modeling approach. Detailed mechanistic models describing chromatographic separation behavior are available, and software to simulate chromatography is becoming more and more available (i.e. DelftChrom, CADET, etc.). A downstream bioseparation process normally consists of multiple chromatographic and conditioning steps, hence, an extreme large design space needs to be investigated. This may lead to prohibitive simulation times, even on state‐of‐the‐art fast computers, when only mechanistic models are used. Besides, model parameters for biologicals are usually unknown, and need to be experimentally obtained. This presentation will show the implementation of a state‐of‐the‐art hybrid bioseparation process design approach using a combination of mechanistic models, artificial neural networks and high throughput experimentation for process development and optimization of the production of industrial relevant biologicals.
ABOUT THE PRESENTER
Marcel is Professor of High Throughput Process Development (HTPD) and Complex Molecules Separation at Delft University of Technology. He is a Board Member of the European Society on Biochemical Engineering Science (ESBES), Guest Board Member of the American Chemical Society – Biotechnology Division, Vice-chair of the Downstream Processing Section ESBES, Board Member of the NBV (Dutch Biotechnological Society) working party on Product Isolation and Purification, Board Member of the Delft Process Technology Institute, Editor of the Journal of Food and Bioproducts Processing and founder of MARLIN Biopurifications. His current research interests are: micro bio systems technology and micro fluidics; bioprocess miniaturization; biologicals separation, purification and characterization; fast conceptual bio(pharma) process design; high temperature throughput process development; process chromatography of biologicals and nutraceuticals; continuous bioprocessing; general phase behavior of biomaterials including crystallization and precipitation and more in general transport phenomena and bioseparation science.
DATE: Thursday, 18 May 2017
VENUE: MSG-025 MSSI Building Extension
TEA/COFFEE WILL BE AVAILABLE AT 13h45
For further information, please contact: email@example.com